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OZONE/OXYGEN IP IN A PRECLINICAL CANCER STUDY* WITH AN

OUTLOOK IN HUMAN-AND VETERINARY MEDICINE (PILOT-RESULTS)

AND OTHER PRE-CLINICAL STUDIES IN DISCUSSION TO HUMAN DISEASE

ENTITIES

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OZONE INTERACTION WITH PAIN MEDIATORS, PRELIMINARY CLINICAL

EVIDENCES

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FLUOROSCOPY- GUIDED PERCUTANEOUS INTRADISCAL OZONE

INJECTION

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ADJUVANT HYPERBARIC OXYGEN AND OZONE THERAPY IN THE

TREATMENT OF CHRONIC LEG AND FOOT ULCERS (PILOT CLINICAL

STUDY)

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OZONE THERAPY IN PATIENTS WITH VIRAL HEPATITIS C TEN YEARS

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OZONE/OXYGEN IP IN A PRECLINICAL CANCER STUDY* WITH AN

OUTLOOK IN HUMAN-AND VETERINARY MEDICINE (PILOT-RESULTS)

AND OTHER PRE-CLINICAL STUDIES IN DISCUSSION TO HUMAN

DISEASE ENTITIES

Introduction. The application of relatively large amounts of Ozone/Oxygen into the abdomen of laboratory animals is one useful technique to control possible therapeutic and/or toxicological effects of this gaseous mixture in different animal models with different disease entities. The aim of this study was to test the effects of an intraperitoneally insufflated gas mixture (called O3/O2-pneumoperitoneum) on the survival rate, the growth of the primary tumorus and metastatic spread of the VX auricle cancer in New Zealand White rabbits.

Materials and methods. The first observations with Ozone/Oxygen ip from few rabbits with VX2 cell induced bi-auricular tumors encouraged us for further preclinical studies with statistical importance.. Altogether 41 male rabbits with an unilateral auricular tumor were used to show the possible efficiacy of ozone/oxygen vs oxygen and sham animals as control by this method of application (O3/O2-PP).

Ozone/Oxygen was insufflated with the Generator Medozon ip, Herrmann Apparatebau, D-Kleinwallstadt, Germany into anaesthesized animals (Metodomidine/Propofol).The single dosis of Ozone/Oxygen was 80 ml gas volume / kg. The concentration was 50 g ozone in 1 ml of the gas mixture. After repetitive insufflations (x 5 dass) from day 14 to 19 after tue tumor cell inoculation, the total amount of ozone was 4 mg/kg. The period of observation was 90 days.

Results. In group O3/O2 (n = 14 rabbits) there was a survival of 50 % compared to O group (n = 13) with 23.1 % survival and compared to the sham group (n = 14) with only 7.1 % survival. There was a total tumor regression and prevention of metastasis in 6 rabbits from O3/O2 group (42.9 %) compared to 2 from the O2 group (15.4 %) and only 1 from sham treatment (7.1 %). Lmph node palpation, body weight development, hematological and clinical chemistry blood parameters, blood gas analysis and microbiological analyses of infected primary tumours were additionally recorded. Finally, the results of an immune suppression study of the cured 6 rabbits and the necropsy of all animals, e. g. weight of parotid lymph nodes and lung metastases will be presented.

Discussion. These preclinical results showed the efficiacy of Ozone/Oxygen ip on an established animal cancer model (VX2). This method of application, called O3/O2PP, has been used in other experimental disease entities, known as pre-clinical studies.



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