WWW.KONFERENCIYA.SELUK.RU

- ,

 

Pages:   || 2 | 3 | 4 |

2012 .. ...

-- [ 1 ] --

. . .

2012

..

2012

[004:57:616-07](082) 32.9743+53.443+28.70743 54 2012 : . . . / . .

54 . . . : - . -, 2012. 292 .: .

ISBN 978-5-292-04136-8 , , , . , .

, , , , .

:

. . (. ), . . (. ), . . , . . , . . [004:57:616-07](082) 32.9743+53.443+28.707

- 20092013 - (ʻ).

ISBN 978-5-292-04136- ,

1.

. . - .......... .. , .. , .. , ..

,

.. , ..

.. , .. , ..

.. , .. , .. , .. -

.. , .. .. .. , ..

.. , .. , ..

.. , ..

-

.. , .. , .. , .. , ..

-I

(GRATIOLA OFFICINALIS)..

. . , . .

.. , ..

,

.. , .. ()

.. , .. , ..

. . , ..

.. , .. , .. , ..

..

..

2. ,

.. , .. , ..

-

GPU

.. , .. -

-



.. , .. , .. - Ȼ

.. , .. , .. , ..

VNTR-

.. , .. , .. , .. , .. , ..

.. , .. .................. .. , .. , .. , ..

-

.. , .. , .. -

..

-

-

.. -

..

.. , ..

.. , .. , .. -

.. , .. , ..

..

-

.. , ..

,

. .

. . , . .

....

.. , . ., .. , .., ..

.. , .. , .. , ..

-

.. , .. , ..

-

..

.. , ..

..

.. , .. TV-

.. , .. , ..

.. , ..

- Ȼ............. .. , .. , ..

.. , .. , .. , .. , ..

-

.. -

..

.. , .. , .. , .. , ..

.. , .. , ..

.. ................. 3.

.. , . , .. , ..

.

.. , .. , . .





188RE....... .. , ..

.. ( )............. .. , .., .. , .., ..

.. -

.. , .. , .. , ..

.. :

.. , .. , .. , .. , .. , ..

, .., .. , ..

:

-

.., ..

.. , .. , .. , .. , .. , ..

-

.. , .. , ..

.. , .. , ..

-

.., ..

.., .., .., ..

.. , . . , . . , . . , . . , . .

.. , .. , ..

..

.. , .. , .. , .. , .. , ..

.. , ..

.. , ..

.., .., .., .., .., .., ..

.. -

.. , .. ˨ SURGITRON DF 120.................. .. , .. , ..

/

.. , .. , ..

..

.. , .. , ..

..

.., .., .. :

.., .., ..

-

.. , .. , .. ............. ..

.. , ..

.. , .. , ..

.. , .. , .. , ..

M.. .., ..

4.

.. , ..

-

.. , .. , ..

.. , .. , ..

.. , .. -

.. , .. , .. , ..

.. , ..

.. , ..

.. , .. , .. , ..

-

..

- .

. . , .. , .. , .. , ..

.. , .. , ..

..

..

GSM

.. , ..

.. , ..

.. , .. , ..

.. , .. -

,

5.

.. , ..

.. , .., .., .., ..

,

.. , .. , .. , .. , ..

.. , .. , .. , .. , .. , ..

.. , .. , .. , .. , .. , ..

.. , .. , .. , .. , ..

.. , .. , .. , .. , .. , ..

.. , .., .. , .. , ..

........ .. , ..

.. , .. , .. , ..

.. , ..

.., ..

.. , .. , .. , ..

-

. 2012 - 20092013 - - (ʻ).

, , , , , , , . 2012 124 14 .

, , , , .

- , , , -, -, , . , , .

1.

-

. . . . .

() . , .

, , (1952), 1962 . , , , , .

. ( ) , . , . .

, , in vitro, , (bath). . , . , , , , . , , .

, , , . , () () () -, , . ( , .), , . () , .

, , , , (spreading cortical depression) () . , , , . - . , .

, . : , .

, ,

, , , , , , .

[110].

1.Postnov D.E., Postnov D.D., Schimansky-Geier L.. Self-terminating wave patterns and selforganized pacemakers in a phenomenological model of spreading depression // Brain Research.

2012. Vol. 1434. P. 200211.

2.Postnov D E., Brazhe N.A., Sosnovtseva O.V. Functional modeling of neural-glial interaction // Biosimulation in Biomedical Research, Health Care and Drug Development, 2011. 350 .

3.Postnov D. E., Koreshkov R. N., Brazhe N. A., Brazhe A. R., Sosnovtseva O. V.. Dynamical patterns of calcium signaling in a functional model of neuronastrocyte networks // J. of Biol.

Phys. 2009. Vol. 35. P. 425445.

4. .., .., ... // . . . 2011. T. 19, 3. . 2644.

5.Postnov D.E., Chetverikov A.P., Postnov D.D. Stimulus-induced response patterns of mediumembedded neurons // Eur. Phys. J. 2010. Special Topics. Vol. 187. P. 241253.

6.Postnov D. E., Muller F., Schuppner R. B., Schimansky-Geier L. Dynamical structures in binary media of potassium-driven neurons // Phys. Rev. E. 2009. Vol. 80. P. 031921.

7. .., .., ... // . .

. 2008. T. 16, 4. . 83100.

8.Postnov D.E., Ryazanova L.S., Brazhe N.A., Brazhe A.R., Maximov G.V., Mosekilde E., Sosnovtseva O.V. Giant Glial Cell: New Insight throuth Mechanism-Based Modeling // J. Biol.

Phys. 2008. Vol. 34. P. 441457.

9.Postnov D.E., Ryazanova L.S., Sosnovtseva O.V. Functional modeling of neural-glial interaction // Biosystems. 2007. Vol. 89 (13). P. 8491.

10. Postnov D.E., Ryazanova L.S., Mosekilde E., Sosnovtseva O.V. Neural Synchronization via Potassium Signaling // Intern. J. of Neural Systems. 2006. Vol. 16, 2. P. 99109.

,

.. , .. , .. , .. . . . , () . , . , , , , . , , , .

, . [1]. [2]. , , Instron 3342. , , . Roteri RCC- 120 W. 1 . , , 1 . [3]. [4] 10 . - . 1, 3, . 2, 4, . , , , 5. - () 7. 8.

.1. - , . , , , .

Instron 3342. h=15 . , , V=2 /. G=2,255 , 9,4 . Instron 3342, , . , .

(. ) , . 5 . . 3%. , .

, , , , . , .

1. .., .., .., .. // .

2012. 3. .6974.

2.Lukianowicz T., Lukianowicz C. Method of measuring of little periodical movements involving laser interferometry // Proc. SPIE. 1994. Vol.2340. P.415422.

3. .., .., .. , , // . 2011. 18. .6572.

4. .., .., .. : // . 2008.

. 1, 1. . 4 10.

-

. . . , . , (). (.1,2).

. 1. - . 2. . , . .

. 20% . , . . (.3 4 ).

. 3. - . 4. - , , 1. .., .. - 2008. . .: - . .. , 2009. 162 .

2. .., .., .., .. // 2009: . . . . . ... : - . -, 2009. . 7680.

3. .., .. // . . - . .. . 4, . 2. . : - . .. , 2011. . 415417.

4. .., .., .. // . . . . -. . .-. . 2011. 3(24).. 7988.

-

.. , .. , .. . .., E-mail: vlasova-olga-andreevna@yandex.ru . , , . [1]. , . . (), [2, 3].

[4] . , -.

- 39 ~82 .%. - [5]. 0.63%- - KI = 1%. .

0.1%- UV2550 Shimadzu, .

-.

, , - (. 1, 2), ~290 ~350 , I3 IO3. ( 1). , 500 .

, [6], , .

, ( ) , - (. 2).

- , ~1673 1377 -1, NH2 . - ~1673 -1 , 1377 -1 . , -, , -.

. 1. - . 2. , I2+KI (1) , - 0.63%- - : (1) 1 (2) KI = 1% (2) . 3. ( ) () ( ) () () (. 3, ) 2 = 10 20, OH NH2. (. 3,) 0.5 1 2 = 22, I NH2, .

- (. 4).

, , , . OH NH2 . 4. .

, - - 10 : - , , , - .

1. .., .., .. // . 2004. .5, 1. .715.

2. : , / . .. , .. , .. . .: , 2002. 368 .

3. .., .. // .

. -. 2010. .15, 4. .11221123.

4. .., .., .. // : . . . -. : . , 2011. .102104.

5. .., .., .., .. // . : , 2011. .203205.

6. .., .., .., .. // . . -. 2010. .15, 3. .

-

.. 1, .. 1, .. 2, .. 1, . .. . , 0.1 [1]. () , , . , . , , . [2].

, , . . , , .

[1]. (), - , , (), . , , . , , .

, :

0 , , , f , z .

(1) , x(t), x(t 0 ) .

, , , A z(t). , , (1), , .

, . , , , . , , [3], . .

, , . , .

( 10-02-00980, 12-02-00377, -4435.2012.8).

1.Malpas S. Neural influences on cardiovascular variability: Possibilities and pitfalls // Am. J. Physiol. Heart Circ. Physiol. 2002. Vol.282. P.6.

2.Ponomarenko V.I., Prokhorov, M.D. Recovery of systems with a linear filter and nonlinear delay feedback in periodic regimes // Phys. Rev. E. 2008. Vol. 78. P. 066207.

3. .., .., .., .. // . 2003. . 29, . 19. . 69.

. .. , . , . , . , , , [1].

, - () . , , . , .

, , . , . Ca2+, Na+, K+, Cl-, , 13 20 [2].

, () . , (.1). , 20 . . , , .

. 1. , (t>20 ), IP3.

: Vm; ISOC,Na, ISOC,Ca , Ca2+; INaK, IPMCA, INCX Na+-K+-, - Na+-Ca2+-, ; [Na+]i, [K+]i, [Cl-]i, [Ca2+]IS IP3- ; IIP3, ISERCA,IS, IP3R, - () , Ileak,IS; K+-Ca2+ Na+- ; IKCa IKir , ; ICaCC, IVRAC Ca2+ Cl--, - , Cl NaKCl-; Ca2+ IP , , , . -1.7 2.45 . , , (. 2). , .

.2. , () , () , , , . , , ( ). , .

1. Figueroa X.F., Chen C.-C., Campbell K.P., Damon D.N., Day K.H., Ramos S., Duling B.R.

Are voltage-dependent ion channels involved in the endothelial cell control of vasomotor tone?

// Am. J. Physiol. Heart Circ Physiol. 2006. Vol. 293. P.13711383.

2.Silva H.S., Kapela A., Tsoukias N.M. A mathematical model of plasma membrane electrophysiology and calcium dynamics in vascular endothelial cells // Am. J. Physiol. Cell Physiol. 2007. Vol. 293. P.277293.

. .. [1] . , , , , , .

, , . .

[2].

, :

S j . , , PI. (100 ), , , , 5%.

, 1 . , . PI, , . . PI, , .

, 1,5 .

, , , , , . , . .

, , , : , , ; ; , .

PI : , b , ; 95% : PI ; PI , - -, , , .. , , , , . , , , .

( 10-02-00980, 12-02-00377 12-02-31274).

1.Granger C.W.J. Investigating causal relations by econometric models and crossspectral methods // Econometrica. 1969. Vol. 37, 3. P. 424.

2.Chen Y., Rangarajan G., Feng J., Ding M. Analyzing Multiple Nonlinear Time Series with Extended Granger Causality. Phys. Let. A. 2004. Vol. 324, Is. 1. P. 26 35.

.. , .. 1, .. . .. , ( ) , 20% . , , , , ..

, , , , , , , [1,2]. , , . , , , Borbly [3], .

(sleep pressure) , 24- (SCN) [4]. SCN, , .

- [5]. . . () ( ), ( ). .

: MA , VLPO , SCN . , [6]. , . ( ) ( ) . , , -, , , . , () , , (""). , , . , [7].

1.Akerstedt T. Work hours, sleepiness and the underlying mechanisms // J. Sleep Res.

1995, Vol.4 P. 1522.

2.Boivin D.B., Tremblay G.M., James F.O. Working on atypical schedules // Sleep Med.

2007. Vol.8 P. 578589.

3.Borbly A.A. A two process model of sleep regulation // Hum Neurobiol. 1982 Vol.1.

P. 95204.

4.Moore R.Y. Suprachiasmatic nucleus in sleep-wake regulation // Sleep Med. 2007. Vol.

8 P. 2733.

5.Postnova S., Layden A., Robinson P.A., Phillips A.J.K., Abeysuriya R. Exploring sleepiness and entrainment on permanent shift schedules in a physiologically based model // J.

Biol. Rhythms. 2012. Vol. 27(1) P. 91102.

6.Czeisler C.A., Johnosn M.P., Duffy J.F., Brown E.N., Ronda J.M. Exposure to bright light and darkness to treat physiologic maladaptation to night work // New Eng. J. Med. 1990.

Vol. 322 P. 12531259.

7.Postnova S., Robinson P.A., Postnov D.D. Adaptation to shift work: physiologically based modeling of the effects of lighting and shifts' start time. PLoS one 2012 (under review).

-

. . . - - () [1, 2] [3], , . - , [4], , - , , (. 1). .

45%, 60% 75% , . ; (. 2), , , (. 3). 60% (. 4) 0.07 /. , (. 5), 60% 0.06/, 75% 0.62/. (. 6, 7) .

. 2. - . 3. - . 4. - . 5. 1. Kim H. J., Vignon-Clementel I.E., Coogan J.S., Figueroa C.A., Jansen K.E., Taylor C.A. Pasient-specific modeling of blood flow and pressure in human coronary arteries. Ann.

Biomed. Eng. 2010. Vol.38(10). P. 31953209.

2. Kim H. J., Vignon-Clementel, I. E., Figueroa, C. A., Jansen, K. E., Taylor, C. A.

Developing computational methods for three-dimensional finite element simulations of coronary blood flow // Finite Elements in Analysis and Design. 2010. Vol.46(6). P. 514525.



Pages:   || 2 | 3 | 4 |
:

- - - (, 1617 2013 .) 3 3 2014 40.7 34 : - . , ., .-. .. ...

, 1945 . , 1972 . ( ) - -. 1977 . , 1978 . ,...

2008 2008 . 1. .., .., .. (5 ), .. // . : .- . , 1(16). 2008. . 85 89. ISSN 1991 8615. 2. .., .. (4 ) ...

XII .. 3 , 2012 330.101.5(063) 65.012 23 . ISBN 978-5-7598-0953-1 (. 3)...

VII , , 20 13 . Ǩ .. 350038, , . , 17 . .. vniimk-zem@yandex.ru + , , , , ...

- - 20 : 20-21 2012 . , - 2012 2 . . 3 ...

- 12-13 2011 .. : .. , .. . .. , ... .. . .. , ... .. ...

(14.03.02) 1. . , , . . . 2. - . 3. . 4. . , , . 5. . 6. . . . 7....

. .. V / - :, . .. , 2013, . V. - 256 . : .. , - (. ) .. , ...

: - . : 11-24-2-88 : . -2011. http://butlerov.com/bh-2011/ 541.1:620.193.01:669.14. 13 2011 . CuSi ...

- - 12-12-22500 2012 338.431.001.76(571.15) 65.32 17 17...

: ABS ( ) () () 2002 . : /Shutterstock ...

5 2014 , 9 5 2014 2 ! 9 5 2014 ...

90- - 23-27 2005 : - .. (IREX) -- 2005 2. 431 : .. , .. ...

2 - 2010 . 24 2010 . - 2010 (-2010), , , . , ...

TD/B/C.I/CLP/27 Distr.: General 29 April 2014 Russian Original: English , 810 2014 3 ) , ...

... 2- - , 2005 784.584(2 537)638.1 2- - , . . / ...- .... :...

- . .. , - I 2014 30 2013 . 9 12.00 I. . : ... .. (15 ) ...

- 1920 2011 - 2011 612.014.482; 657.1:0/9 53.6; 65.052.9(2)2[65.052.9] : , , 1920 2011 . : , 2011. 312 . ISBN 978-5-93929-206-1 ...

4- , - , . , . .. , 27 31 2008 622:001.12/18:504.062(1/9);620.9+502.7+614.87 - ...









 
<<     |    
2014 www.konferenciya.seluk.ru - - ,

, .
, , , , 1-2 .