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:

7.

..

. ..

,

- (COSY) - (HSQC) :

LOMONOSOV MOSCOW STATE UNIVERSITY

Credit to: Norbert Hertkorn, LOMONOSOV MOSCOW STATE Defence GSF, presentation for Dr. Habil. UNIVERSITY

- 13 -

(0.1 NaOD) , .. 13 CH-, 0.5-1.95 5-48 -, - . .

. . - 1.95-3. -H . / . CH3-O 3.1-4.7 48-58 H2-O,N 58-64 O- N- CH-O,N 64- () O-CH-O,N 4.7-6.0 90-108 . ., Ar-, 6.0-10.0 108-145 -, - . .

Ar-,N - 145-165 , N- . .

- 165-187 . . -,C - 187-220 =

LOMONOSOV MOSCOW STATE UNIVERSITY

13

CAlkO C=O COO ArO Ar OCO CHn

LOMONOSOV MOSCOW STATE UNIVERSITY

0 ppm 200 150 100

13

C, ..

C, .. 0. 0.

PFA-T4H98 PFA-T5H98 0.

0. SFA-Pw PFA-T6H98 PFA-T7H PFA-T10L98 PFA-TTL98 SFA-Pg 0. 0. SFA-Pw SFA-Pp 0. 0. 0. 0.

0. 0.

LOMONOSOV MOSCOW STATE UNIVERSITY

LOMONOSOV MOSCOW STATE UNIVERSITY

,

COSY 23J(H,H) HSQC, 1J(H,) X-H HMQC HMBC nJ(H,) X-H NOESY, NOM/HS HOESY

LOMONOSOV MOSCOW STATE UNIVERSITY

COSY

LOMONOSOV MOSCOW STATE UNIVERSITY

1H,13 HSQC

LOMONOSOV MOSCOW STATE UNIVERSITY

1H,1H COSY

LOMONOSOV MOSCOW STATE UNIVERSITY

-

LOMONOSOV MOSCOW STATE UNIVERSITY

ACD/2D NMR - SOFTWARE

LOMONOSOV MOSCOW STATE UNIVERSITY

H,H COSY

HSQC

Carbon No. CHn Value Error

LOMONOSOV MOSCOW STATE UNIVERSITY

H-C CARBOHYDRATES HSQC SBASE (Brucker)

OH OH O OH

Fucose

HO O OH HO

OH OH OH

Mannose-d

LOMONOSOV MOSCOW STATE UNIVERSITY

1,13-HSQC

(SBASE)

H-H COSY

(SBASE, Bruker) Carbohydrates

?

?

?

LOMONOSOV MOSCOW STATE UNIVERSITY

1H,13 HSQC

LOMONOSOV MOSCOW STATE UNIVERSITY

1H,1H COSY

:

(. 1990)

LOMONOSOV MOSCOW STATE UNIVERSITY

:

PHA-T798 PHA-T10L PHA-T798 PHA-T10L

LOMONOSOV MOSCOW STATE UNIVERSITY

:

1H,13CCOSY PHA-T7

LOMONOSOV MOSCOW STATE UNIVERSITY

HSQC

LOMONOSOV MOSCOW STATE UNIVERSITY

SPARIA-

LOMONOSOV MOSCOW STATE UNIVERSITY

SPARIA-

LOMONOSOV MOSCOW STATE UNIVERSITY

SPARIA-

LOMONOSOV MOSCOW STATE UNIVERSITY

1. .

2. .

3.

4.

- !

LOMONOSOV MOSCOW STATE UNIVERSITY

!

LOMONOSOV MOSCOW STATE UNIVERSITY

:

- 23.03.2006, 15:30, . 16 :

LOMONOSOV MOSCOW STATE UNIVERSITY

SPARIA-

LOMONOSOV MOSCOW STATE UNIVERSITY

LOMONOSOV MOSCOW STATE UNIVERSITY

-C-O-H + (H3C)3Si-Y = -C-O-Si(CH3)3 + HY

LOMONOSOV MOSCOW STATE UNIVERSITY

-

=>

=> 15N ,

LOMONOSOV MOSCOW STATE UNIVERSITY

19F

, , - CDCl (Leenheer J.A., Noyes T.I., 1989) , ., 1998, :

LOMONOSOV MOSCOW STATE UNIVERSITY

( ):

2 HA + Ba(OH)2 BaA2 + H2O ( ) ( ):

2 HA + Ca(OAc)2 CaA2 + 2 AcOH ( ):

(ArOH; COOH) - COOH = ArOH

LOMONOSOV MOSCOW STATE UNIVERSITY



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